Gymnema sylvestre extract as a Traditional Medicine For Diabetes Mellitus

Abstract

Diabetes Mellitus (DM) is a metabolic desease characterized by
hyperglycemia and resulting in impaired insulin resistance (Lila et al., 2023; Kashif et
al., 2023). According to the World Health Organization (WHO), in 2019 DM cases
with a prevalence of 1.5 million deaths and 48% occurred before the age of 70 years.
Indonesia is in seventh position with 10.7 million DM cases and will continue to
increase until 2045 (WHO, 2019). Diabetes mellitus sufferers prefer herbal medicine
because it is cheap, easy to buy, safe, does not cause side effects, and contains natural
ingredients (Hamzah, 2019). Gymnemwa sylvestre (G. sylvestre) is a plant found in
central and western India, Africa and Australia. This plant is an anti-diabetic plant
that has been used for centuries as a traditional medicine (Khan et al., 2019).
Gymnemwa sylvestre is a plant found in central and western India, Africa, Australia,
and grows in tropical countries such as Indonesia, China, Malaysia (Kashif et al.,
2023). This plant is a traditional medicine that has been used for centuries as an
antidiabetic (Khan et al., 2019).
Research purposes is to determine the effect of Gymnema sylvestre extract as
an antidiabetic in experimental animals treated with diabetes mellitus (DM). The type
of research carried out was a journal review.
The results of the research were that Gymnemwa sylvestre extract doses 120,
200, 250, 400, 500, 900mg/kg were injected into experimental animals of rats or
rabbits treated for diabetes mellitus. Blood samples were examined for lipid profiles
(total cholesterol, LDL, HDL, triglycerides) with the results showing a significant
reduction, so that G.sylvestre extract was able to reduce hyperglycemia.
Keyword : Diabetes Mellitus, Gymnema sylvestre, Lipid Profile